?? ???? ????? ???? ????? ?? ?????? ??????? ?????? ?????? ??? ???? ????? ?? ??? ???????? ??? ?? ??? ????? ???? ????? ?? ???? ?? ??? ???? ??????? ?? ?????? ????? ???? ?????? ????? ??????.OPANA is indicated for your relief of moderate to serious acute agony the place using an opioid is appropriate.Other than contributing to overdoses, abuse of Opana E